In different transplantable and transgenic mouse tumor models we identified M1-like MHC IIhi and M2-like MHC IIlow macrophages, that perform distinct functions and are located in normoxic and hypoxic tumor regions, respectively.

We currently investigate:

  1. the relative in vivo contribution of each TAM subset to tumor characteristics (growth, metastasis, vessel function, etc),
  2. the intratumoral microenvironmental signals that govern the TAM subset phenotype,
  3. the bidirectional interaction between TAM subsets and tumor-infiltrating lymphocytes.